فى الصيدلية

دواء دوكسيل doxil المضاد للسرطان بتقنية جديدة للتقليل من آثاره الجانبية

Mohamed Elshennawy

اخر تحديث :

دواء دوكسيل doxil المضاد للسرطان بتقنية جديدة للتقليل من آثاره الجانبية

* دواء دوكسوروبيسين Doxorubicin تابع لعائلة Anthracyclines

ودي بتيجى من احد سلالات البكتريا Streptomyces.

دواء دوكسوروبيسين Doxorubicin يعتبر من أشهر الأدوية المضادة للسرطان على الإطلاق واللى بتستخدم على نطاق واسع جداً فى أنواع عديدة من السرطان وبيدخل فى نظم عديدة.

معروف أن عائلة Anthracyclines ليها سمية عالية أنها تعمل CARDIOTOXICITY، يعنى سمية فى القلب وفشل قلبى.

* في أدوية تندرج تحت إسم فينكا Alkaloids زى Vincristine و Vinblastine دا دواء وكذلك مضاد للسرطان مستخلص من النبات بيشتغل على الـ Microtubule ودى من اهم ال cytoskeleton بتاع الخلية.

العائلة دي ليها سمية في الأعصاب Neuropathy (الأعصاب الطرفية) عالية جداً.

مؤخراً تم تطوير الأدوية دي في صورة Liposome علشان يقلل من السمية بتاعتهم عن طريق إيصال الدواء سريعاً للخلايا.

وتم تطوير المنتجات دي بتغليفها بطبقة الليبوسوم، مثل دواء Vincristine المطور في منتج (Marqibo).

ومثل دواء Doxorubicin المطور في منتج (Doxil).

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